The observed insufficient a substantial accumulation of PHN in brain subsequent the intraventricular administration of (+)-amphetamine and also the development of appreciable quantities of PHN from (+)-POH in brain tissue in vivo supports the look at the aromatic hydroxylation of amphetamine pursuing its systemic administration occurs predominantly during the periphery, and that POH is then transported with the blood-brain barrier, taken up by noradrenergic neurones in brain where (+)-POH is converted from the storage vesicles by dopamine β-hydroxylase to PHN. ^
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